Table 1. Homology families, proposed activities, and functions of S. cerevisiae nuclear kinesins

Motor Family Activity Putative homologues at kinetochores References
Cin8p/Kip1p Kinesin-5 Cross-linking/ sliding None Hoyt et al., 1992; Roof et al., 1992; Saunders and Hoyt, 1992; Gordon and Roof, 1999; Kapitein et al., 2005;
Kip3p Kinesin-8 Depolymerizing/metaphase chromosome attachment S. pombe: klp5/klp6; West et al., 2001, 2002; Garcia et al., 2002a,b; Rogers et al., 2004;
Kinesin-13 Metaphase chromosome attachment D. melanogaster: KLP67A, KLP10A, KLP59C Maney et al., 1998, 2001; Desai et al., 1999; Severin et al., 2001; Lawrence et al., 2004; Moore and Wordeman, 2004; Rogers et al., 2004; Sharp and Rogers, 2004; Mennella et al., 2005
Kar3p Kinesin-14 Depolymerizing note: Kar3p has two different cofactors; Cik1 for mating cells and Vik1 for vegetatively growing cells None Meluh and Rose, 1990; Endow et al., 1994; Manning et al., 1999; Sproul et al., 2005

Kip3p has variously been placed in the kinesin-8/-13 families by different investigators and has occasionally been described as a KinI kinesin.

References

Desai, A., S. Verma, T.J. Mitchison, and C.E. Walczak. 1999. Kin I kinesins are microtubule-destabilizing enzymes. Cell. 96:69–78.

Garcia, M.A., N. Koonrugsa, and T. Toda. 2002a. Spindle-kinetochore attachment requires the combined action of Kin I- like Klp5/6 and Alp14/Dis1-MAPs in fission yeast. EMBO J. 21:6015–6024.

Garcia, M.A., N. Koonrugsa, and T. Toda. 2002b. Two kinesin-like Kin I family proteins in fission yeast regulate the establishment of metaphase and the onset of anaphase A. Curr. Biol. 12:610–621.

Lawrence, C.J., R.K. Dawe, K.R. Christie, D.W. Cleveland, S.C. Dawson, S.A. Endow, L.S. Goldstein, H.V. Goodson, N. Hirokawa, J. Howard, et al. 2004. A standardized kinesin nomenclature. J. Cell Biol. 167:19–22.

Maney, T., A.W. Hunter, M. Wagenbach, and L. Wordeman. 1998. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J. Cell Biol. 142:787–801.

Maney, T., M. Wagenbach, and L. Wordeman. 2001. Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin. J. Biol. Chem. 276:34753–34758.

Manning, B.D., J.G. Barrett, J.A. Wallace, H. Granok, and M. Snyder. 1999. Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J. Cell Biol. 144:1219–1233.

Mennella, V., G.C. Rogers, S.L. Rogers, D.W. Buster, R.D. Vale, and D.J. Sharp. 2005. Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase. Nat. Cell Biol. 7:235–245.

Severin, F., B. Habermann, T. Huffaker, and T. Hyman. 2001. Stu2 promotes mitotic spindle elongation in anaphase. J. Cell Biol. 153:435–442.

Sharp, D.J., and G.C. Rogers. 2004. A Kin I-dependent Pacman-flux mechanism for anaphase A. Cell Cycle. 3:707–710.

West, R.R., T. Malmstrom, C.L. Troxell, and J.R. McIntosh. 2001. Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast. Mol. Biol. Cell. 12:3919–3932.